The Journal of Organic Chemistry

Intramolecular Friedel-Crafts reaction of 3-cyclohexen-1-acetyl chloride and its 4-methyl analog

SA Monti, GL White

Index: Monti,S.A.; White,G.L. Journal of Organic Chemistry, 1975 , vol. 40, # 2 p. 215 - 217

Full Text: HTML

Citation Number: 21

Abstract

The intramolecular Friedel-Crafts acylation of aliphatic substrates to give fused-ring products is well documented. 2, 3 This method also provides an attractive synthetic route to bicyclic derivatives characterized by differentiated functionality in two bridge^.^ An investigation of the Lewis acid catalyzed cyclization of 3-cyclohexen-1-acetyl chloride (1) and its 4-methyl analog 2 was undertaken to evaluate further this approach to functionalized bicyclooctane ...

 Related Synthetic Route
(4-methylcyclohex-3-en-1-yl)methanol Structure

39155-38-9

(4-methylcycloh...

~%

2-cyclohex-3-en-1-ylethanol Structure

18240-10-3

2-cyclohex-3-en...

ethyl 4-methylcyclohex-3-ene-1-carboxylate Structure

20292-15-3

ethyl 4-methylc...

~%

2-cyclohex-3-en-1-ylethanol Structure

18240-10-3

2-cyclohex-3-en...

4-Methyl-3-cyclohexen-1-acetonitril Structure

53216-76-5

4-Methyl-3-cycl...

~%

2-cyclohex-3-en-1-ylethanol Structure

18240-10-3

2-cyclohex-3-en...

2-(4-methylcyclohex-3-en-1-yl)acetic acid Structure

7086-66-0

2-(4-methylcycl...

~%

2-cyclohex-3-en-1-ylethanol Structure

18240-10-3

2-cyclohex-3-en...

4-methyl-3-cyclohexene-1-acetyl chloride Structure

7086-72-8

4-methyl-3-cycl...

~%

2-cyclohex-3-en-1-ylethanol Structure

18240-10-3

2-cyclohex-3-en...

4-Methyl-3-cyclohexen-1-acetonitril Structure

53216-76-5

4-Methyl-3-cycl...

~%

2-(4-methylcyclohex-3-en-1-yl)acetic acid Structure

7086-66-0

2-(4-methylcycl...

(4-methylcyclohex-3-en-1-yl)methanol Structure

39155-38-9

(4-methylcycloh...

~%

2-(4-methylcyclohex-3-en-1-yl)acetic acid Structure

7086-66-0

2-(4-methylcycl...

4-methyl-3-cyclohexene-1-acetyl chloride Structure

7086-72-8

4-methyl-3-cycl...

~%

bicyclo[3.2.1]oct-3-en-6-one Structure

31444-32-3

bicyclo[3.2.1]o...

(4-methylcyclohex-3-en-1-yl)methanol Structure

39155-38-9

(4-methylcycloh...

~%

bicyclo[3.2.1]oct-3-en-6-one Structure

31444-32-3

bicyclo[3.2.1]o...

ethyl 4-methylcyclohex-3-ene-1-carboxylate Structure

20292-15-3

ethyl 4-methylc...

~%

bicyclo[3.2.1]oct-3-en-6-one Structure

31444-32-3

bicyclo[3.2.1]o...

4-Methyl-3-cyclohexen-1-acetonitril Structure

53216-76-5

4-Methyl-3-cycl...

~%

bicyclo[3.2.1]oct-3-en-6-one Structure

31444-32-3

bicyclo[3.2.1]o...

2-(4-methylcyclohex-3-en-1-yl)acetic acid Structure

7086-66-0

2-(4-methylcycl...

~%

bicyclo[3.2.1]oct-3-en-6-one Structure

31444-32-3

bicyclo[3.2.1]o...


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