Gastric anti-secretory, anti-ulcer and cytoprotective properties of substituted (E)-4-phenyl-and heteroaryl-4-oxo-2-butenoic acids

…, A Butti, Y Christidis, J Perronnet, F Barzaghi…

Index: Bianchi, Mario; Butti, Alina; Christidis, Yani; Perronnet, Jacques; Barzaghi, Fernando; et al. European Journal of Medicinal Chemistry, 1988 , vol. 23, p. 45 - 52

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Citation Number: 24

Abstract

Abstract A class of anti-secretory, anti-ulcer and cytoprotective agents, the substituted (E)-4- phenyl and heteroaryl-4-oxo-2-butenoic acids, is described. This chemical structure is not related to those of any known anti-cholinergic drugs, histamine H 2-receptor antagonists or prostaglandins. Five compounds, 4-(2-methoxyphenyl)-15, 4-(4-methoxyphenyl)-22, 4-(3, 4- dimethoxyphenyl)-32, 4-(3, 4, 5-trimethoxyphenyl)-40, and 4-(2-furanyl)-4-oxo-2-butenoic ...