Substituent effects on the genotoxicity of 4-nitrostilbene derivatives

BH Hooberman, MD Brezzell, SK Das, Z You…

Index: Hooberman; Brezzell; Das; You; Sinsheimer Mutation Research - Genetic Toxicology, 1994 , vol. 341, # 1 p. 57 - 69

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Citation Number: 7

Abstract

Abstract 4-Nitrostilbene and twelve of its derivatives (eleven E-stilbenes and two Z-stilbenes) were examined for possible quantitative structure-activity relationships of their in vitro and in vivo genotoxicity. Relative mutagenicity was studied with and without S9 activation in Salmonella strains TA98 and TA100, as well as in the nitroreductase deficient strains TA98/NR and TA100/NR. Chromosomal aberrations in the bone-marrow cells of mice ...