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e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Synthesis of indoles from N-(trifluoroacetyl)-2-anilino acetals

JE Nordlander, DB Catalane, KD Kotian…

Index: Journal of Organic Chemistry, , vol. 46, p. 778 - 782

Full Text: HTML

Citation Number: 49

Abstract

... (3) (a) Sundberg, R. J. “The Chemistry of Indoles ... J. Org. ... The organic layer was washed with water and dried over anhydrous MgSOk Distillation gave 10.6 g (35 mmol, 97%) of pale yellow 2 (X = H), which darkened progressively on being allowed to stand: bp 97-100 "C (0.5 mm ...

 Related Synthetic Route
2,2,2-trifluoro-1-(5-methyl-1H-indol-1-yl)ethanone Structure

582319-44-6

2,2,2-trifluoro...

~%

5-Methylindole Structure

614-96-0

5-Methylindole

N1-(2,2-DIETHOXYETHYL)-4-METHYLANILINE Structure

75934-28-0

N1-(2,2-DIETHOX...

~%

5-Methylindole Structure

614-96-0

5-Methylindole

N-(2,2-diethoxyethyl)-2,2,2-trifluoro-N-(p-tolyl)acetamide Structure

75934-36-0

N-(2,2-diethoxy...

~%

5-Methylindole Structure

614-96-0

5-Methylindole

[N-(3-Methyl-phenyl)-amino]-acetaldehyd-diaethylacetal; N m-methylphenyl aminoacetal diethylique Structure

75934-29-1

[N-(3-Methyl-ph...

~%

4-Methyindole Structure

16096-32-5

4-Methyindole

N-(2,2-diethoxyethyl)-2,2,2-trifluoro-N-(m-tolyl)acetamide Structure

75934-37-1

N-(2,2-diethoxy...

~%

6-Methyl-1H-indole Structure

3420-02-8

6-Methyl-1H-indole

4-Methyindole Structure

16096-32-5

4-Methyindole

[N-(3-Methyl-phenyl)-amino]-acetaldehyd-diaethylacetal; N m-methylphenyl aminoacetal diethylique Structure

75934-29-1

[N-(3-Methyl-ph...

~%

6-Methyl-1H-indole Structure

3420-02-8

6-Methyl-1H-indole

3-Toluidine Structure

108-44-1

3-Toluidine

~%

6-Methyl-1H-indole Structure

3420-02-8

6-Methyl-1H-indole

N-(2,2-diethoxyethyl)-2,2,2-trifluoro-N-(m-tolyl)acetamide Structure

75934-37-1

N-(2,2-diethoxy...

~%

6-Methyl-1H-indole Structure

3420-02-8

6-Methyl-1H-indole

4-Methyindole Structure

16096-32-5

4-Methyindole

N/A Structure

75934-26-8

N/A

~%

4,6-Dimethylindole Structure

75948-77-5

4,6-Dimethylindole

3,5-Dimethylaniline Structure

108-69-0

3,5-Dimethylaniline

~%

4,6-Dimethylindole Structure

75948-77-5

4,6-Dimethylindole

N-trifluoroacetyl-3-methylindole Structure

82342-81-2

N-trifluoroacet...

~%

3-Methylindole Structure

83-34-1

3-Methylindole

Benzenamine,N-(2-chloro-2-propen-1-yl)- Structure

15332-67-9

Benzenamine,N-(...

~%

3-Methylindole Structure

83-34-1

3-Methylindole

2,2,2-trifluoro-N-(2-oxopropyl)-N-phenylacetamide Structure

75934-43-9

2,2,2-trifluoro...

~%

3-Methylindole Structure

83-34-1

3-Methylindole

N-(2-chloroallyl)-2,2,2-trifluoro-N-phenylacetamide Structure

75934-44-0

N-(2-chloroally...

~%

3-Methylindole Structure

83-34-1

3-Methylindole

N-(2,2-diethoxyethyl)-N-(3,5-dimethylphenyl)-2,2,2-trifluoroacetamide Structure

75934-34-8

N-(2,2-diethoxy...

~%

4,6-Dimethylindole Structure

75948-77-5

4,6-Dimethylindole

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Detail Synthetic Route


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