Tetrahedron Letters

Ligand free open air copper (II) mediated aryl formamidation and amination of aryl halides

R Komati, BS Jursic

Index: Komati, Rajesh; Jursic, Branko S. Tetrahedron Letters, 2014 , vol. 55, # 9 p. 1523 - 1527

Full Text: HTML

Citation Number: 1

Abstract

Abstract A simple synthetic procedure for direct formamidation and amination of aryl halides mediated by copper (II) salts was developed in open air, without an external ligand in formamide with potassium carbonate as a base. This approach is particularly efficient when electron active aryl halides are used as substrates. In these cases almost quantitative formamidation was observed.