Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics

AP Combs, EW Yue, M Bower, PJ Ala…

Index: Journal of Medicinal Chemistry, , vol. 48, # 21 p. 6544 - 6548

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Citation Number: 86

Abstract

... Journal of Medicinal Chemistry. ... research and drug discovery. PTP1B was the first PTP purified 3,4 in the 1980s and has been extensively studied within academia and the pharmaceutical industry. It is regarded by ...