Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics

AP Combs, EW Yue, M Bower, PJ Ala…

文献索引：Journal of Medicinal Chemistry, , vol. 48, # 21 p. 6544 - 6548

全文：HTML全文

被引用次数: 86

摘要

... Journal of Medicinal Chemistry. ... research and drug discovery. PTP1B was the first PTP purified 3,4 in the 1980s and has been extensively studied within academia and the pharmaceutical industry. It is regarded by ...