In an investigation of the anti-inflammatory properties of five-membered ring nitrogen- containing heterocyclic compounds, two series of derivatives of imidazole were prepared by altering the sites of substitution and by joining aliphatic chains to the nitrogen atom in the 1 position of the imidazole ring. Some of them were more potent inhibitors of carragenan- induced edema than indomethacin. An electron spin resonance study indicated that these ...
