Synthesis and structure–activity relationship of botryllamides that block the ABCG2 multidrug transporter

K Takada, N Imamura, KR Gustafson…

Index: Takada, Kentaro; Imamura, Nobutaka; Gustafson, Kirk R.; Henrich, Curtis J. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 4 p. 1330 - 1333

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Citation Number: 20

Abstract

In previous work, botryllamides discovered from the marine ascidian Botryllus tyreus were characterized as selective inhibitors of the ABCG2 multidrug transporter. However, the structural basis for this activity could not be established. In this study, botryllamide F, the ...