Synthesis

Synthesis of quaternary alkylammonium sulfobetaines

RS Ward, J Davies, G Hodges, DW Roberts

Index: Ward, Robert S.; Davies, Joanna; Hodges, Geoffrey; Roberts, David W. Synthesis, 2002 , # 16 p. 2431 - 2439

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Citation Number: 20

Abstract

Abstract A series of quaternary alkylammonium sulfobetaines of general formula RN+(CH 3) 2 (CH 2) n SO 3-, where n= 2-4, have been synthesised by reacting the corresponding N, N- dimethylamines with either sodium 2-chloroethanesulfonate (n= 2), 1, 3-propanesultone (n= 3), or 1, 4-butanesultone (n= 4). Full details of the preparation of the required N, N- dimethylamines are reported.