Electrochemical models for cytochrome P-450. N-Demethylation of tertiary amides by anodic oxidation

LR Hall, RT Iwamoto, RP Hanzlik

Index: Hall, Larry R.; Iwamoto, Reynold T.; Hanzlik, Robert P. Journal of Organic Chemistry, 1989 , vol. 54, # 10 p. 2446 - 2451

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Citation Number: 48

Abstract

Figure 1. Mechanistic pathways for N-dealkylations of amines by cytochrome P-450 enzymes. Path a illustrates the" abstraction-recombination" mechanism, in which EFe= O represents the oxo-iron form of the hemoprot6in and EFe is the ferric form of the enzyme (formally two equivalents lower in oxidation state than EFe= O). Pathway b illustrates the" aminium ion" mechanism; the electron acceptor is assumed to be the oxo-iron form of P- ...