Sodium methoxide: a simple but highly efficient catalyst for the direct amidation of esters

…, K Agura, Y Fujii, A Yoshiyama, K Mashima

Index: Ohshima, Takashi; Hayashi, Yukiko; Agura, Kazushi; Fujii, Yuka; Yoshiyama, Asako; Mashima, Kazushi Chemical Communications, 2012 , vol. 48, # 44 p. 5434 - 5436

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Citation Number: 55

Abstract

Amides are one of the most ubiquitous and important functional groups in natural and synthetic organic compounds, and the amide bond formation has been intensively investigated in organic synthesis. 1 In vivo, protein synthesis (amide bond formation) is performed by ribosomes 2 and the key to this transformation is the catalytic amidation of esters. In the non-enzymatic amide formation, however, esters are viewed as an inert scaffold upon which traditional ...