Tetrahedron Letters

Asymmetric organocatalytic reduction of ketimines with catecholborane employing a N-triflyl phosphoramide Brønsted acid as catalyst

D Enders, A Rembiak, M Seppelt

Index: Enders, Dieter; Rembiak, Andreas; Seppelt, Matthias Tetrahedron Letters, 2013 , vol. 54, # 6 p. 470 - 473

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Citation Number: 13

Abstract

The first asymmetric reduction of ketimines with catecholborane employing an enantiopure N-triflyl phosphoramide as the organocatalyst has been developed. Five mole% of the catalyst provides the corresponding secondary amines in very good to almost quantitative yields and good enantioselectivities up to 86: 14 er under mild reaction conditions.