Identification of optimal anion spacing for anti-HIV activity in a series of cosalane tetracarboxylates

…, E De Clercq, C Pannecouque, M Witvrouw…

Index: Paul, Gitendra C.; De Clercq, Erik; Pannecouque, Christophe; Witvrouw, Myriam; Loftus, Tracy L.; Turpin, Jim A.; Buckheit Jr., Robert W.; Cushman, Mark Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 18 p. 2149 - 2152

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Citation Number: 10

Abstract

The binding of the anti-HIV agent cosalane to CD4 is thought to involve ionic interactions of negatively charged carboxylates of the ligand with positively charged residues on the surface of the protein. An investigation of the optimal anion distances for anti-HIV activity in a series of cosalane tetracarboxylate analogues has been completed, and maximal activity results when the two proximal and the two distal carboxylates are separated by eight ...