Organic letters

BINOLAM, a recoverable chiral ligand for bifunctional enantioselective catalysis: The asymmetric synthesis of cyanohydrins

J Casas, C Nájera, JM Sansano, JM Saá

Index: Casas, Jesus; Najera, Carmen; Sansano, Jose M.; Saa, Jose M. Organic Letters, 2002 , vol. 4, # 15 p. 2589 - 2592

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Citation Number: 126

Abstract

A new bifunctional catalytic system based on a monometallic aluminum complex is used for the efficient enantioselective cyanation of aldehydes. The ligand (S)-or (R)-2, 2'-bis (diethylaminomethyl)-substituted binaphthol (BINOLAM) used is recovered for recycling. This methodology is used for the synthesis of a precursor of epothilone A.

~99%

~97%

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