Tetrahedron

A new (R)-hydroxynitrile lyase from Prunus mume: asymmetric synthesis of cyanohydrins

S Nanda, Y Kato, Y Asano

Index: Nanda, Samik; Kato, Yasuo; Asano, Yasuhisa Tetrahedron, 2005 , vol. 61, # 46 p. 10908 - 10916

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Citation Number: 57

Abstract

A new hydroxynitrile lyase (HNL) was isolated from the seed of Japanese apricot (Prunus mume). The enzyme has similar properties with HNL isolated from other Prunus species and is FAD containing enzyme. It accepts a large number of unnatural substrates (benzaldehyde and its variant) for the addition of HCN to produce the corresponding cyanohydrins in excellent optical and chemical yields. A new HPLC based enantioselective assay ...

~80%

~88%

~65%

~80%

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