Inhibition of oleamide hydrolase catalyzed hydrolysis of the endogenous sleep-inducing lipid cis-9-octadecenamide

JE Patterson, IR Ollmann, BF Cravatt…

Index: Patterson, Jean E.; Ollmann, Ian R.; Cravatt, Benjamin F.; Boger, Dale L.; Wong, Chi-Huey; Lerner, Richard A. Journal of the American Chemical Society, 1996 , vol. 118, # 25 p. 5938 - 5945

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Citation Number: 101

Abstract

Oleamide (1, cis-9-octadecenamide) is a naturally occurring brain constituent that has been shown to accumulate and disappear under conditions of sleep deprivation and sleep recovery, respectively. Synthetic 1 has been found to induce sleep in a structurally specific manner at nanomolar quantities. Hydrolysis of 1 by an enzyme (oleamide hydrolase) present in the cell membrane rapidly degrades oleamide to oleic acid (cis-9-octadecenoic ...