Fluorinated tricyclic neuroleptics with prolonged action: 7-Fluoro-11-[4-(2-hydroxyethyl) piperazino]-2-isopropyl-10, 11-dihydrodibenzo [b, f] thiepin

M Protiva, J Jílek, M Rajšner…

Index: Protiva, Miroslav; Jilek, Jiri; Rajsner, Miroslav; Pomykacek, Josef; Ryska, Miroslav; et al. Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 3 p. 698 - 722

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Citation Number: 8

Abstract

Abstract Substitution reaction of 11-chloro-7-fluoro-2-isopropyl-10, 11-dihydrodibenzo [b, f,] thiepin with 1-(2-hydroxyethyl) piperazine gave the title compound I which proved a very potent and longacting oral neuroleptic agent (isofloxythepin). Its resolution by means of dibenzoyl-(+)-and-(-)-tartaric acid led to (-)-and (+)-enantiomer out of which the former represents the neuroleptically active component. In the synthetic sequence leading to I, ...