Synthesis and Evaluation of 6, 7-Dihydroxy-2, 3, 4, 8, 9, 13b-hexahydro-1H-benzo [6, 7] cyclohepta [1, 2, 3-ef][3] benzazepine, 6, 7-Dihydroxy-1, 2, 3, 4, 8, 12b- …

…, FA Aviles-Garay, R Chakraborti…

Index: Snyder, Scott E.; Aviles-Garay, Felix A.; Chakraborti, Ratna; Nichols, David E.; Watts, Val J.; Mailman, Richard B. Journal of Medicinal Chemistry, 1995 , vol. 38, # 13 p. 2395 - 2409

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Citation Number: 50

Abstract

The present study was designed to define the geometry of the hydrophobic accessory region for binding of dopamine D1 receptor ligands and to assess the relative importance of ethylamine side chain conformation for receptor affinity. Three compounds, 6, 7-dihydroxy-2, 3, 4, 8, 9, 13b-hexahydro-1H-benzo [6, 7lcyclohepta [1, 2, 3-e~[3lbenzazepine, 4, 6, 7- dihydroxy-l, 2, 3, 4, 8, 12b-hexahydroanthr [l0, 4a, 4-~ d] azepine, 5, and 10-(aminomethy1 ...