Synthesis and Evaluation of 6, 7-Dihydroxy-2, 3, 4, 8, 9, 13b-hexahydro-1H-benzo [6, 7] cyclohepta [1, 2, 3-ef][3] benzazepine, 6, 7-Dihydroxy-1, 2, 3, 4, 8, 12b- …

…, FA Aviles-Garay, R Chakraborti…

文献索引：Snyder, Scott E.; Aviles-Garay, Felix A.; Chakraborti, Ratna; Nichols, David E.; Watts, Val J.; Mailman, Richard B. Journal of Medicinal Chemistry, 1995 , vol. 38, # 13 p. 2395 - 2409

全文：HTML全文

被引用次数: 50

摘要

The present study was designed to define the geometry of the hydrophobic accessory region for binding of dopamine D1 receptor ligands and to assess the relative importance of ethylamine side chain conformation for receptor affinity. Three compounds, 6, 7-dihydroxy-2, 3, 4, 8, 9, 13b-hexahydro-1H-benzo [6, 7lcyclohepta [1, 2, 3-e~[3lbenzazepine, 4, 6, 7- dihydroxy-l, 2, 3, 4, 8, 12b-hexahydroanthr [l0, 4a, 4-~ d] azepine, 5, and 10-(aminomethy1 ...