MIRC reactions. 3. Use of doubly activated substrates

RD Little, R Verhe, WT Monte, S Nugent…

Index: Little, R. Daniel; Verhe, Roland; Monte, William T.; Nugent, Sean; Dawson, James R. Journal of Organic Chemistry, 1982 , vol. 47, # 2 p. 362 - 364

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Citation Number: 29

Abstract

We recently reported the formation of three-, five-, six-, and seven-membered-ring esters bearing P-heteroatom substituents, through the utilization of what we have termed a MIRC (Michael Initiated Ring Closure) reacti0n. l Herein, we provide (1) a rationale for the use of geminate doubly activated w-halo a,@-unsaturated esters rather than monoactivated systems as substrates for the MIRC reaction and (2) evidence which demonstrates that the ...