N-(benzyloxycarbonyl) glycine esters and amides as new anticonvulsants

M Geurts, JH Poupaert, GKE Scriba…

Index: Geurts, Muriel; Poupaert, Jacques H.; Scriba, Gerhard K. E.; Lambert, Didier M. Journal of Medicinal Chemistry, 1998 , vol. 41, # 1 p. 24 - 30

Full Text: HTML

Citation Number: 43

Abstract

Glycine is a small neutral amino acid exhibiting weak anticonvulsant activities in vivo. Recently, studies have demonstrated that N-(benzyloxycarbonyl) glycine (1) antagonized seizures superior to glycine in addition to activity in the maximal electroshock (MES) test, a convulsive model where glycine is inactive. In the present study a series of ester and amide derivatives of 1 as well as esters of N-(3-phenylpropanoyl) glycine (5) have been ...

~43%

~16%

~70%

… )??2??cyanoacetate (Boc??Oxyma) as Coupling Reagent for Ra...

[Thalluri, Kishore; Nadimpally, Krishna Chaitanya; Chakravarty, Maharishi Parasar; Paul, Ashim; Mandal, Bhubaneswar Advanced Synthesis and Catalysis, 2013 , vol. 355, # 2-3 p. 448 - 462]

Catalyst and solvent-free amidation of inactive esters of N-...

[Nadimpally, Krishna Chaitanya; Thalluri, Kishore; Palakurthy, Nani Babu; Saha, Abhijit; Mandal, Bhubaneswar Tetrahedron Letters, 2011 , vol. 52, # 20 p. 2579 - 2582]

A food effect study of an oral thrombin inhibitor and prodru...

[Dosa, Stefan; Stirnberg, Marit; Luelsdorff, Verena; Haeussler, Daniela; Maurer, Eva; Guetschow, Michael Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 21 p. 6489 - 6505,17]

Preparation of Carboxamides via Carboxylic-Phosphoric Anhydr...

[Gaede, Bruce Organic Process Research and Development, 1999 , vol. 3, # 2 p. 92 - 93]

Peptide Synthesis via Oxidation of N-Acetyl-α-amino Acid Phe...

[Milne,H.B.; Kilday,W. Journal of Organic Chemistry, 1965 , vol. 30, p. 64 - 66]