Organic Process Research & Development

Preparation of Carboxamides via Carboxylic-Phosphoric Anhydrides

B Gaede

Index: Gaede, Bruce Organic Process Research and Development, 1999 , vol. 3, # 2 p. 92 - 93

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Citation Number: 4

Abstract

A number of reagents used to prepare carboxamides via a carboxylic-phosphoric anhydride intermediate have been reexamined. It was found that a simple carboxylic-phosphoric anhydride prepared from a carboxylic acid and commercially available diethyl chlorophosphate provided several significant advantages over more complex intermediates in many cases.