Design, synthesis, and biological evaluation of chalcone oxime derivatives as potential immunosuppressive agents

Y Luo, R Song, Y Li, S Zhang, ZJ Liu, J Fu…

Index: Luo, Yin; Song, Ran; Li, Yao; Zhang, Shuai; Liu, Zhi-Jun; Fu, Jie; Zhu, Hai-Liang Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3039 - 3043

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Citation Number: 20

Abstract

A series of deoxybenzoin oximes were recently reported as potent immunosuppressive agents by our group. In order to continue the original research for potential immunosuppressive agents with high efficacy and low toxicity, we synthesized a series of new chalcone oximes and evaluated them for their cytotoxicities and immunosuppressive activities. Among the synthesized compounds, chalcone oximes 25 and 27 exhibited ...