Design, synthesis, and biological evaluation of chalcone oxime derivatives as potential immunosuppressive agents

Y Luo, R Song, Y Li, S Zhang, ZJ Liu, J Fu…

文献索引：Luo, Yin; Song, Ran; Li, Yao; Zhang, Shuai; Liu, Zhi-Jun; Fu, Jie; Zhu, Hai-Liang Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3039 - 3043

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被引用次数: 20

摘要

A series of deoxybenzoin oximes were recently reported as potent immunosuppressive agents by our group. In order to continue the original research for potential immunosuppressive agents with high efficacy and low toxicity, we synthesized a series of new chalcone oximes and evaluated them for their cytotoxicities and immunosuppressive activities. Among the synthesized compounds, chalcone oximes 25 and 27 exhibited ...