Abstract Analogs of 7α-hydroxy-4-cholesten-3-one were prepared to ascertain structural features necessary for maximal activity of hepatic microsomal 12α-steroid hydroxylase. Methyl 3α, 7α-dihydroxy-5β-cholane-24-carboxylate derived from chenodeoxycholic acid was oxidized at C-3 with silver carbonate/Celite. The product was hydrolyzed and dehydrogenated with SeO 2 to provide 3-oxo-7α-hydroxy-4-cholene-24-carboxylic acid. ...
![(3R,5S,7R,8R,9S,10S,12S,13R,14S)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triol Structure](https://image.chemsrc.com/caspic/186/18866-87-0.png)