Journal of the American Chemical Society

The preparation of C-27 steroids from bile acids. I. Coprostanetetrol-3 (α), 7 (α), 12 (α), 25

WH Pearlman

Index: Pearlman Journal of the American Chemical Society, 1947 , vol. 69, p. 1475

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Citation Number: 24

Abstract

The preparation of coprostanetetrol-3 (a), i (a), 12 (a), 25 was considered desirable for the study of the intermediary metabolism involved in the biological conversion of cholesterol to cholic acid. 2 One of the metabolic routes obviously requires the removal of the terminal isopropyl group in the side-chain of the cholesterol skeleton. On the basis of chemical analogy, the oxidative attack in vivo may very well begin with the introduction of oxygen on ...