Steroids

Bile acids. LXXIII. Synthesis of analogs of 7α-hydroxy-4-cholesten-3-one as substrates for hepatic steroid 12α-hydroxylase

MJ Joyce, SV Hiremath, MB Mattammal, WH Elliott

文献索引：Joyce, Michael J.; Hiremath, S. V.; Mattammal, Michael B.; Elliott, William H.; Doisy, Edward A. Steroids, 1984 , vol. 44, # 1 p. 95 - 102

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被引用次数: 5

摘要

Abstract Analogs of 7α-hydroxy-4-cholesten-3-one were prepared to ascertain structural features necessary for maximal activity of hepatic microsomal 12α-steroid hydroxylase. Methyl 3α, 7α-dihydroxy-5β-cholane-24-carboxylate derived from chenodeoxycholic acid was oxidized at C-3 with silver carbonate/Celite. The product was hydrolyzed and dehydrogenated with SeO 2 to provide 3-oxo-7α-hydroxy-4-cholene-24-carboxylic acid. ...