Computer-aided rational drug design: a novel agent (SR13668) designed to mimic the unique anticancer mechanisms of dietary indole-3-carbinol to block Akt …

WR Chao, D Yean, K Amin, C Green…

Index: Journal of Medicinal Chemistry, , vol. 50, # 15 p. 3412 - 3415

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Citation Number: 73

Abstract

... Journal of Medicinal Chemistry. ... Analogs 6 to 9 were designed and synthesized to determine the optimal N−N' distance for anticancer activity (Table 1 and Scheme 1). DIM (2) was used as the initial scaffold for chemical modification. ...