e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Journal of heterocyclic chemistry

Bioactive heterocyclic analogs of the antitumor drug, podophyllotoxin

L Jurd

Index: Journal of Heterocyclic Chemistry, , vol. 25, # 1 p. 89 - 96

Full Text: HTML

Citation Number: 10

Abstract

... reagents to yield cyclic pro- ducts which provide a simple route to bioactive, synthetic heterocyclic analogs of ... 6.5 6.5 4с + Propionaldehyde 12h C!SH2705N 119-120° 65 69.6 69.5 6.8 6.8 3.5 3.5 Vol. ... ОДСНз), 4.31 (d, J = 12 Hz, CH), 5.80 (d, J = 1 Hz and 5.86, J = 10 Hz, 0СН20 ...

NSC 370284 Structure

2-Butanone Structure

~68%

1-[6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]chromen-6-yl]pyrrolidine Structure

1-[6,7-dimethyl...

Sesamol Structure

~%

1-[6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]chromen-6-yl]pyrrolidine Structure

1-[6,7-dimethyl...

3,4,5-Trimethoxybenzaldehyde Structure

3,4,5-Trimethox...

~%

1-[6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]chromen-6-yl]pyrrolidine Structure

1-[6,7-dimethyl...

Pyrrolidine Structure

Sesamol Structure

3,4,5-Trimethoxybenzaldehyde Structure

3,4,5-Trimethox...

~90%

NSC 370284 Structure

6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]chromen-6-ol Structure

6,7-dimethyl-8-...

~%

8H-1,3-Dioxolo(4,5-g)(1)benzopyran, 6,7-dimethyl-8-(3,4,5-trimethoxyph enyl)- Structure

8H-1,3-Dioxolo(...

Methanol Structure

1-((7R,8S)-8-(4-methoxyphenyl)-6,7-dimethyl-7,8-dihydro-6H-[1,3]dioxolo[4,5-g]chromen-6-yl)pyrrolidine Structure

1-((7R,8S)-8-(4...

~79%

6-methoxy-8-(4-methoxyphenyl)-6,7-dimethyl-7,8-dihydro-[1,3]dioxolo[4,5-g]chromene Structure

6-methoxy-8-(4-...

Sesamol Structure

~%

6-methoxy-8-(4-methoxyphenyl)-6,7-dimethyl-7,8-dihydro-[1,3]dioxolo[4,5-g]chromene Structure

6-methoxy-8-(4-...

4-Methoxybenzaldehyde Structure

4-Methoxybenzal...

~%

6-methoxy-8-(4-methoxyphenyl)-6,7-dimethyl-7,8-dihydro-[1,3]dioxolo[4,5-g]chromene Structure

6-methoxy-8-(4-...

6-((4-methoxyphenyl)(pyrrolidin-1-yl)methyl)benzo[d][1,3]dioxol-5-ol Structure

6-((4-methoxyph...

~%

6-methoxy-8-(4-methoxyphenyl)-6,7-dimethyl-7,8-dihydro-[1,3]dioxolo[4,5-g]chromene Structure

6-methoxy-8-(4-...

Sesamol Structure

~%

6-methoxy-6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]chromene Structure

6-methoxy-6,7-d...

3,4,5-Trimethoxybenzaldehyde Structure

3,4,5-Trimethox...

~%

6-methoxy-6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]chromene Structure

6-methoxy-6,7-d...

1-[6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]chromen-6-yl]pyrrolidine Structure

1-[6,7-dimethyl...

~%

6-methoxy-6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]chromene Structure

6-methoxy-6,7-d...

NSC 370284 Structure

~%

6-methoxy-6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]chromene Structure

6-methoxy-6,7-d...

Methanol Structure

6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]chromen-6-ol Structure

6,7-dimethyl-8-...

~%

6-methoxy-6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]chromene Structure

6-methoxy-6,7-d...