Synthesis of Maleic Anhydrides and Maleic Acids by Pd??Catalyzed Oxidative Dicarbonylation of Alk??1??ynes

B Gabriele, L Veltri, G Salerno, M Costa…

Index: Gabriele, Bartolo; Veltri, Lucia; Salerno, Giuseppe; Costa, Mirco; Chiusoli, Gian Paolo European Journal of Organic Chemistry, 2003 , # 9 p. 1722 - 1728

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Citation Number: 25

Abstract

Abstract We have found that carbon dioxide effectively promotes the Pd-catalyzed oxidative carbonylation of terminal alkynes to give maleic anhydrides in fair yields. Reactions were carried out in aqueous dioxane at 60− 80 C in the presence of catalytic amounts of PdI 2 in conjunction with KI and under a 4: 1: 10 mixture of CO/air/CO 2 (60 atm total pressure at 25 C). By working in the presence of a large excess of water, maleic acids were formed ...