Protein structure-based design, synthesis, and biological evaluation of 5-thia-2, 6-diamino-4 (3 H)-oxopyrimidines: Potent inhibitors of glycinamide ribonucleotide …

MD Varney, CL Palmer, WH Romines…

Index: Journal of Medicinal Chemistry, , vol. 40, # 16 p. 2502 - 2524

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Citation Number: 42

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. Shown in Scheme 1 is the general strategy for the synthesis of the monocyclic 5-thiapyrimidinones 5−13. The key reaction in the sequence is the base-initiated coupling of ...

Synthesis and biological activity of acyclic analogs of 5, 1...

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Redox states of well-defined π-conjugated oligothiophenes fu...

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Synthesis and Antitumour Activity of New Derivatives of Flav...

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Synthesis of 2-thiophenecarboxylic and 2, 5-thiophenedicarbo...

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Synthesis and biological activity of acyclic analogs of 5, 1...

[Journal of Medicinal Chemistry, , vol. 35, # 6 p. 1109 - 1116]