Synthesis and biological activity of acyclic analogs of 5, 10-dideaza-5, 6, 7, 8-tetrahydrofolic acid

…, LS Gossett, JF Worzalla, SM Rinzel…

Index: Shih, Chuan; Gossett, Lynn S.; Worzalla, John F.; Rinzel, Sharon M.; Grindey, Gerald B.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1109 - 1116

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Citation Number: 37

Abstract

The synthesis and biological evaluation of a number of analogues of N-[4 [4 (2, 4-diamino-l, 6-dihydro-6-0~ 0-5-py-rimidyl) butyl] be~ yl]-~ glutamic acid (2)(% DM-DDATHF), an acyclic modification of the novel folate antimetabolite 5, 10-dideazatetrahydrofolic acid (DDATHF), are described. The synthetic procedure utilized previously for the synthesis of 2, lS, and 16 was extended to the preparation of analoguea modified in the benzoyl region with ...