Tetrahedron Letters

A novel method for the synthesis of 2, 2-diaryl-1, 1-difluoroethenes

JH Choi, IH Jeong

Index: Choi, Ji Hoon; Jeong, In Howa Tetrahedron Letters, 2008 , vol. 49, # 6 p. 952 - 955

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Citation Number: 14

Abstract

β, β-Difluoro-α-phenylvinylstannane 3 was prepared in 60% yield from the reaction of β, β- difluoro-α-phenylvinylsulfone 2 with tributyltin hydride in refluxing benzene for 5h. The cross- coupling reaction of 3 with aryl iodides bearing substituents such as proton, fluoro, chloro, bromo, methoxy, methyl, trifluoromethyl, and nitro on ortho, meta, para positions of the benzene ring in the presence of 10mol% Pd (PPh3) 4/10mol% CuI afforded the ...