Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes

…, GK Wagner, DA Kotschenreuther…

Index: Laufer, Stefan A.; Wagner, Gerd K.; Kotschenreuther, Dunja A.; Albrecht Journal of Medicinal Chemistry, 2003 , vol. 46, # 15 p. 3230 - 3244

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Citation Number: 101

Abstract

A series of polysubstituted pyridin-4-yl imidazole inhibitors of p38 MAP (mitogen-activated protein) kinase was prepared as small molecular anticytokine agents and drug candidates for the treatment of chronic inflammatory diseases. The contribution of substituents at the pyridinyl and imidazole moiety to selective inhibition of p38 without concomitant cytochrome P450 interaction was evaluated. Placement of a 1-phenylethyl (7e, p38: IC50 0.38 μM) or ...