Synthesis

Cobalt (II) Chloride Hexahydrate-Diisopropylamine Catalyzed Mild and Chemoselective Reduction of Carboxylic Esters with Sodium Borohydride

AR Jagdale, AS Paraskar, A Sudalai

Index: Jagdale, Arun R.; Paraskar, Abhimanyu S.; Sudalai, Arumugam Synthesis, 2009 , # 4 p. 660 - 664

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Citation Number: 5

Abstract

Abstract The cobalt-catalyzed reduction of unsaturated α-cyano carboxylic esters using sodium borohydride (NaBH 4) leads to the corresponding saturated cyano alcohols in high yields. In particular, the new catalytic system cobalt (II) chloride-diisopropylamine in combination with NaBH 4 showed excellent activity in the chemoselective reduction of a variety of carboxylic esters to their corresponding alcohols in good to excellent yields ...