Tetrahedron letters

Simple deprotection of acetal type protecting groups under neutral conditions

H Miyake, T Tsumura, M Sasaki

Index: Miyake, Hideyoshi; Tsumura, Takatsugu; Sasaki, Mitsuru Tetrahedron Letters, 2004 , vol. 45, # 39 p. 7213 - 7215

Full Text: HTML

Citation Number: 18

Abstract

When acetals such as MOM ethers, MEM ethers, and THP ethers were heated in ethylene glycol or propylene glycol, solvolysis proceeded smoothly to produce alcohols in excellent yield. This reaction is a very promising method for chemoselective deprotection of acetal type protecting groups.