Oxazolines. XI. Synthesis of functionalized aromatic and aliphatic acids. Useful protecting group for carboxylic acids against Grignard and hydride reagents

AI Meyers, DL Temple, D Haidukewych…

Index: Meyers,A.I. et al. Journal of Organic Chemistry, 1974 , vol. 39, p. 2787 - 2793

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Citation Number: 205

Abstract

The use of an oxazoline to mask a carboxyl group is described. Since the oxazoline moiety is inert to Grignard reagents and lithium aluminum hydride, this technique serves as a novel means to elaborate or functionalize carboxylic acid derivatives. The carboxyl function may be masked either as its acid or ester derivative under generally mild conditions. A series of substituted benzoic acids, using the Grignard reagent of the 0-, m-, or p-bromo derivatives ...