Aziridination of alkenes using 3-acetoxyamino-2-trifluoromethylquinazolin-4 (3H)-one

RS Atkinson, MP Coogan, CL Cornell

Index: Atkinson, Robert S.; Coogan, Michael P.; Cornell, Clive L. Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 2 p. 157 - 166

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Abstract

Oxidation of 3-amino-2-trifluoromethylquinazolin-4 (3)-one 6 with lead tetraacetate in dichloromethane gives the title 3-acetoxyamino derivative 7 which is isolable at room temperature and considerably more stable than the corresponding 2-alkyl substituted analogues. Compound 7 aziridinates alkenes in yields which a

~38%

~55%

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