Journal of the American Chemical Society

Steric Effects in Elimination Reactions. X. Steric Strains as a Factor in Controlling the Direction of Bimolecular Eliminations. The Hofmann Rule as a Manifestation of …

HC Brown, I Moritani

Index: Brown; Moritani Journal of the American Chemical Society, 1956 , vol. 78, p. 2203,2209

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Citation Number: 25

Abstract

It was previously proposed that the direction of bimolecular eliminations is controlled L,,..,,. cvilJ~ gative stabilization of the incipient ol&n and by steric strains in the transition state. Such strains in the transition state can be increased by (1) increasing the steric requirements of alkyl groups attached to the incipient double bond,(2) increasing the steric requirements of the attacking base and (3) increasing the steric requirements of the leaving group. ...