Journal of the American Chemical Society

Steric Effects in Elimination Reactions. X. Steric Strains as a Factor in Controlling the Direction of Bimolecular Eliminations. The Hofmann Rule as a Manifestation of …

HC Brown, I Moritani

文献索引：Brown; Moritani Journal of the American Chemical Society, 1956 , vol. 78, p. 2203,2209

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被引用次数: 25

摘要

It was previously proposed that the direction of bimolecular eliminations is controlled L,,..,,. cvilJ~ gative stabilization of the incipient ol&n and by steric strains in the transition state. Such strains in the transition state can be increased by (1) increasing the steric requirements of alkyl groups attached to the incipient double bond,(2) increasing the steric requirements of the attacking base and (3) increasing the steric requirements of the leaving group. ...