Synthesis of 1, 6-Disubstituted 4, 5, 6, 7-Tetrahydropyrazolo [3, 4-c] pyridin-7-one Derivatives and Evaluation of Their Anticancer Activity

VN Devegowda, SH Seo, AN Pae…

Index: Devegowda, Vani Nelamane; Seo, Seon Hee; Pae, Ae Nim; Nam, Ghilsoo; Choi, Kyung Il Bulletin of the Korean Chemical Society, 2012 , vol. 33, # 2 p. 647 - 650

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Citation Number: 2

Abstract

Promising anticancer compounds of the type 1, 6-disubstituted 4, 5, 6, 7-tetrahydropyrazolo [3, 4-c] pyridin-7-ones were identified. The target compounds were readily synthesized in a large scale via a sequence of reactions starting from the commercially available primary amines. Their in vitro anti-proliferative activity has been evaluated on prostate (DU-145), colon (HT-29 and HCT-116) and melanoma (A375P) human cancer cell lines. The ...