New modified heterocyclic phenylalanine derivatives. Incorporation into potent inhibitors of human renin

TD Ocain, DD Deininger, R Russo…

Index: Ocain, Timothy D.; Deininger, David D.; Russo, Ralph; Senko, Nancie A.; Katz, Alan; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 5 p. 823 - 832

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Citation Number: 14

Abstract

Results Chemistry. The choice for the P1 binding group was norstatine (or ACHBA), since extended P'binding sites are not required15J6 and the overall size of the inhibitor is thus reduced. Synthesis of the norstatine unit followed those of the literature."-19 Briefly, Boc- cyclohexylalanine