New modified heterocyclic phenylalanine derivatives. Incorporation into potent inhibitors of human renin

TD Ocain, DD Deininger, R Russo…

文献索引：Ocain, Timothy D.; Deininger, David D.; Russo, Ralph; Senko, Nancie A.; Katz, Alan; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 5 p. 823 - 832

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被引用次数: 14

摘要

Results Chemistry. The choice for the P1 binding group was norstatine (or ACHBA), since extended P'binding sites are not required15J6 and the overall size of the inhibitor is thus reduced. Synthesis of the norstatine unit followed those of the literature."-19 Briefly, Boc- cyclohexylalanine