Spiro hydantoin aldose reductase inhibitors

…, RC Schnur, JL Belletire, MJ Peterson

Index: Sarges; Schnur; Belletire; Peterson Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 230 - 243

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Citation Number: 88

Abstract

Concentration that causes a 50% inhibition of partially purified calf lens aldose reductase with glyceraldehyde as substrate. Single determination; the reproducibility of the assay did not vary by more than 10%? Oral dose, given tid, that causes a 50% reduction in sorbitol levels of sciatic nerve of streptozotocinized rats. 8 If the> or< sign is used, the percent inhibition found is shown in parentheses; in these cases, the percent inhibition produced ...