Medicinal Chemistry Research

Synthesis of analogues of antihyperglycemic lead karanjin

PP Yadav, AK Srivastava, R Maurya

Index: Akanksha; Yadav, Prem P.; Srivastava, Arvind K.; Maurya, Rakesh Medicinal Chemistry Research, 2011 , vol. 20, # 9 p. 1465 - 1472

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Citation Number: 2

Abstract

Abstract Karanjin isolated in gram scale from Pongamia pinnata was subjected to transformation reactions and 11 analogues were prepared and evaluated for their antihyperglycemic activity in streptozotocin-induced diabetic rats, and compared with the standard drug metformin at the dose of 100 mg/kg body weight. Four derivatives showed comparable activity with metformin.

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[Tojino, Mami; Hirose, Yuriko; Mizuno, Mamoru Tetrahedron Letters, 2013 , vol. 54, # 52 p. 7124 - 7126]