Medicinal Chemistry Research

Synthesis of analogues of antihyperglycemic lead karanjin

PP Yadav, AK Srivastava, R Maurya

文献索引：Akanksha; Yadav, Prem P.; Srivastava, Arvind K.; Maurya, Rakesh Medicinal Chemistry Research, 2011 , vol. 20, # 9 p. 1465 - 1472

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被引用次数: 2

摘要

Abstract Karanjin isolated in gram scale from Pongamia pinnata was subjected to transformation reactions and 11 analogues were prepared and evaluated for their antihyperglycemic activity in streptozotocin-induced diabetic rats, and compared with the standard drug metformin at the dose of 100 mg/kg body weight. Four derivatives showed comparable activity with metformin.