Tetrahedron

A combinatorial access to 1, 5-benzodiazepine derivatives and their evaluation for aldose reductase inhibition

…, J Stephanidou-Stephanatou, CA Tsoleridis, C Zika…

Index: Pozarentzi, Minodora; Stephanidou-Stephanatou, Julia; Tsoleridis, Constantinos A.; Zika, Chariklia; Demopoulos, Vassilis Tetrahedron, 2009 , vol. 65, # 36 p. 7741 - 7751

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Citation Number: 17

Abstract

Aryldiazepinothiophenones 4 were prepared from the reaction of o-phenylenediamines with acetone in the presence of 2-mercaptocarboxylic acids along with thiazolobenzodiazepines 6, thiazolobenzimidazoles 7 and 1, 5-benzodiazepines 5, which were obtained as by- products. The benzodiazepinothiophenones 4a–d and the benzodiazepines 5a–d were also isolated from the reaction of o-phenylenediamines 1a–c with phorone. Structural ...