Multisite Solid Catalyst for Cascade Reactions: The Direct Synthesis of Benzodiazepines from Nitro Compounds

MJ Climent, A Corma, S Iborra…

Index: Climent, Maria J.; Corma, Avelino; Iborra, Sara; Santos, Laura L. Chemistry - A European Journal, 2009 , vol. 15, # 35 p. 8834 - 8841

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Citation Number: 31

Abstract

Abstract Substituted 1, 5-benzodiazepines are selectively synthesized in one pot from substituted nitroaromatics and ketones. The reaction is performed in the presence of hydrogen and in the absence of solvent by using a bifunctional solid catalyst with a chemoselective hydrogenation functional group capable of reducing the nitro group to a diamino group and an acid functional group, which catalyzes the cyclocondensation of the ...