Tetrahedron

1, 2-Asymmetric Induction in the Conjugate Addition of Organocopper Reagents to γ-Aryl α, β-Unsaturated Carbonyl Derivatives

…, Y Ono, S Nishii, H Kitahara, S Ito, Y Yamamoto

Index: Chounan, Yukiyasu; Ono, Yasuo; Nishii, Shinji; Kitahara, Haruo; Ito, Shoei; Yamamoto, Yoshinori Tetrahedron, 2000 , vol. 56, # 18 p. 2821 - 2831

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Citation Number: 22

Abstract

The diastereoselectivity in the conjugate addition of organocopper reagents to γ-aryl α, β- unsaturated carbonyl derivatives 8–14 was investigated. The syn-diastereoselectivity was obtained irrespective of the reagents type in the addition of 8, while the anti- diastereoselectivity was obtained in the addition of 10–14 with RCu and RCu (CN) Li (R= Me and Bu) and the syn-selectivity was produced in the addition of 10–14 with R2CuLi ...